an extensible tuplespace as XML-middleware

XMLSpaces.NET implements the Linda concept as a middleware for XML documents. It introduces an extended matching flexibility on nested tuples and richer data types for fields, including objects and XML documents. It is completely XML-based since data, tuples and tuplespaces are seen as trees represented as XML documents. XMLSpaces.NET is extensible in that it supports a hierarchy of matching relations on tuples and an open set of matching amongst data, documents and objects. It is currently being implemented on the .NET platform

XMLSpaces.NET: An Extensible Tuplespace as XML Middleware

XMLSpaces.NET implements the Linda concept as a middleware for XML documents on the.NET platform. It introduces an extended matching flexibility on nested tuples and richer data types for fields, including objects and XML documents. It is completely XML-based since data, tuples and tuplespaces are seen as trees represented as XML documents. XMLSpaces.NET is extensible in that it supports a hierarchy of matching relations on tuples and an open set of matching amongst data, documents and objects.

Unbedingte Besonderheit? Aufgaben und Konturen einer Politischen Philosophie der Besonderheit

Flügel-Martinsen O, Martinsen F. Unbedingte Besonderheit? Aufgaben und Konturen einer Politischen Philosophie der Besonderheit. In: Liebsch B, Staudigl M, eds. Bedingungslos? Zum Gewaltpotenzial unbedingter Ansprüche im Kontext der politischen Theorie. Baden-Baden: Nomos; 2014: 111-126

Semantic Web Spaces

In this paper we present an extension of XML-based tuplespaces for the Semantic Web. This proposal draws on the ideas of tuplespace computing as a paradigm closer to the basic principles of the Web. We describe the evolution of tuplespace computing, outline why tuplespaces are a suitable middleware for the Semantic Web and suggest how XMLSpaces can be extended to support Semantic Web technologies, like RDF(S) and OWL. 1

A Coordination Middleware for the Semantic Web

Abstract. The Semantic Web marks the next generation of worldwide networked information systems. In order to build Semantic Web applications, some middleware is necessary to offer uniform access to distributed information. We propose a coordination middleware called Semantic Web Spaces in which we extend the common Linda model with views on information in order to handle Semantic Web-based knowledge representation in a space. Finally, we report on a current implementation of our concept.

Biallelic gephyrin variants lead to impaired GABAergic inhibition in a patient with developmental and epileptic encephalopathy

Synaptic inhibition is essential for shaping the dynamics of neuronal networks, and aberrant inhibition is linked to epilepsy. Gephyrin (Geph) is the principal scaffolding protein at inhibitory synapses and is essential for postsynaptic clustering of glycine (GlyRs) and GABA type A receptors. Consequently, gephyrin is crucial for maintaining the relationship between excitation and inhibition in normal brain function and mutations in the gephyrin gene (GPHN) are associated with neurodevelopmental disorders and epilepsy. We identified bi-allelic variants in the GPHN gene, namely the missense mutation c.1264G > A and splice acceptor variant c.1315-2A > G, in a patient with developmental and epileptic encephalopathy. We demonstrate that the splice acceptor variant leads to nonsense-mediated mRNA decay. Furthermore, the missense variant (D422N) alters gephyrin structure, as examined by analytical size exclusion chromatography and circular dichroism-spectroscopy, thus leading to reduced receptor clustering and sensitivity towards calpain-mediated cleavage. In addition, both alterations contribute to an observed reduction of inhibitory signal transmission in neurons, which likely contributes to the pathological encephalopathy